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KMID : 0614720150580080745
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Journal of Korean Medical Association
2015 Volume.58 No. 8 p.745 ~ p.749
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Combination pharmacotherapy in lipid management
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Lee Sang-Hak
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Abstract
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Latest guidelines on lipid management recommend statins as the first-line therapy. Because limited evidence is available on cardiovascular outcomes with varying statin-nonstatin combinations, recommendation levels for these regimens have been weak. However, a recent trial has demonstrated the additive effect of the statin-ezetimibe combination. The statin-fibrate combination has shown an effect in certain subgroups and on diabetic microangiopathy. Recent trials using the statin-niacin combination have been largely negative, whereas the statin-omega-3 fatty acids combination demonstrated a positive effect only in one study. Identifying the benefits and limitations of each combination is important for the best possible management of patients.
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KEYWORD
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Ezetimibe, Fibric acids, Niacin, Fatty acids, omega-3
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